NCRRN.org

Annotated Citations

fMRI issues relevant to clinical studies

• Detre, J.A. and T.F. Floyd (2000) Functional MRI and its applications to the clinical neurosciences. Neuroscientist, 7: 64-79.

  This review article provides a broad overview of the principles of fMRI and its application to a variety of clinical disorders (JD).

• Detre, J.A. and J. Wang (2002) Technical aspects and utility of fMRI using BOLD and ASL. Clin. Neurophysiol., 113: 621-634.

  This review article covers the biophysical characteristics of blood oxygenation level dependent (BOLD) and arterial spin labeled (ASL) perfusion MRI (JD).

• Roc, A.C., J. Wang, B.M. Ances, D.S. Liebeskind, S.E. Kasner and J.A. Detre (2006) Altered hemodynamics and regional cerebral blood flow in patients with hemodynamically significant stenoses. Stroke, 37: 382-7.

  This report demonstrates alterations in hemodynamics and fMRI responses in patients with chronic cerebrovascular disease (JD).

• Crinion J, Ashburner J, Leff A, Brett M, Price C, Friston K. Spatial normalization of lesioned brains: performance evaluation and impact on fMRI analyses. Neuroimage. 2007 Sep 1;37(3):866-75. Epub 2007 May 24. PMID 17616402

  This article addresses the issue of how different spatial normalization techniques can affect functional imaging data from the brains of patients with focal lesions. (JK).

Pefusion fMRI methodology

• Aguirre, G.K., J.A. Detre and D.C. Alsop (2002) Experimental design and the relative sensitivity of BOLD and perfusion fMRI. Neuroimage, 15: 488-500.

  This paper provides the theoretical framework and experimental validation demonstrating the potential of ASL perfusion fMRI for measuring changes in brain function over prolonged periods (JD).

• Floyd, T.F., S.J. Ratcliffe, J.J. Wang, B., Resch and J.A. Detre (2003) Precision of the CASL-perfusion MRI technique: Global and regional cerebral blood flow within vascular territories at one hour and one week. J. Magn. Reson. Imaging, 18: 649-55.

  This paper demonstrates the test-retest sensitivity of CBF values from perfusion fMRI obtained at 1.5 Tesla (JD).

• Wang, J., G.K. Aguirre, D.Y. Kimberg, A.C. Roc, L. Li and J.A. Detre (2003) Arterial spin labeling perfusion fMRI with very low task frequency. Magn Reson Med, 49: 796-802.

  This paper follows Aguirre et al., 2000 and uses motor activation to demonstrate the stability of perfusion fMRI for visualizing task activation over long periods. Successful detection of activation versus rest on subsequent days is demonstrated. (JD).

• Aguirre, G.K., J.A. Detre and J. Wang (2005) Perfusion fMRI for functional neuroimaging. Int Rev Neurobiol, 66: 213-36.

  This review article provides and updated summary of the benefits of perfusion fMRI in cognitive neuroimaging (JD).

• Fernandez-Seara, M.A., Z. Wang, J. Wang, H.Y. Rao, M. Guenther, D.A. Feinberg and J.A. Detre (2005) Continuous arterial spin labeling perfusion measurements using single shot 3D GRASE at 3 T. Magn Reson Med, 54: 1241-7.

  This article describes a methods for single-shot 3-dimensional perfusion fMRI (JD).

• Newberg, A.B., J. Wang, H. Rao, R.L. Swanson, J.S. Karp, A. Alavi, J.H. Greenberg and J.A. Detre (2005) Concurrent CBF and CMRGlc changes during human brain acitvation by combined fMRI-PET scanning. Neuroimage, 28: 500-6.

  This article describes a method for concurrent measurement of CBF and glucose utilization using fMRI and PET scanning. This approach may be useful in examining the coupling between blood flow and metabolism in pathological states such as stroke recovery (JD).

• Wang, Z., J. Wang, T.J. Connick, G.S. Wetmore and J.A. Detre (2005) Continuous ASL perfusion MRI with an array coil and parallel imaging at 3T. Magn Reson Med, 54: 732-7.

  This article demonstrates the benefits of parallel imaging for perfusion fMRI (JD).

Applications of perfusion fMRI to cognitive neuroscience

• Wang, J., H. Rao, G.S. Wetmore, P.M. Furlan, M. Korczykowski, D.F. Dinges and J.A. Detre (2005) Perfusion functional MRI reveals cerebral blood flow pattern under psychological stress. Proc Natl Acad Sci U S A, 102: 17804-9.

  This article uses perfusion fMRI to visualize the neural response to psychological stress using a calculation task performed under time pressure (JD).

• Kim, J., J. Whyte, J. Wang, H. Rao, K.Z. Tang and J.A. Detre (2006) Continuous ASL perfusion fMRI investigation of higher cognition: Quantification of tonic CBF changes during sustained attention and working memory tasks. Neuroimage.

  Utilizing a recently developed perfusion fMRI protocol, this article demonstrate that CASL method can be used successfully for the investigation of subtle changes of CBF during tasks tapping higher cognitive processes. Considering the usefulness of perfusion fMRI in the field of clinical neuroscience, this article will provide guidance to future studies applying this technique to the study of cognitive dysfunctions in various clinical populations.(JK)

• Olson, I.R., H. Rao, K.S. Moore, J. Wang, J.A. Detre and G.K. Aguirre (2006) Using perfusion fMRI to measure continuous changes in neural activity with learning. Brain Cogn.
• Jefferson, A.L., G. Glosser, J.A. Detre, G. Sinson and D.S. Liebeskind (2006) Neuropsychological and perfusion MR imaging correlates of revascularization in a case of moyamoya syndrome. AJNR Am J Neuroradiol, 27: 98-100.

  This case report demonstrates a correlation between perfusion fMRI and cognitive function and a dissociation between functional and structural MRI (JD).