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Areas of Expertise

Imaging informatics

NCRRN researchers have developed systems for collecting and analyzing structural lesion information, along with statistical approaches to exploring lesion/behavior relationships (Kimberg).

Annotated Citations
  • Bates, E., Wilson, S. M., Saygin, A. P., Dick, F., Sereno, M. I., Knight, R. T. & Dronkers, N. F. (2003). Voxel-based lesion-symptom mapping. Nature Neuroscience, 6, 448-450.

    This brief but important article spells out the goals of voxel-based methods for mapping lesion-behavior correlations, and coins the term VLSM for voxel-based lesion-symptom mapping.

  • Charil A, Zijdenbos AP, Taylor J, Boelman C, Worsley KJ, Evans AC, Dagher A. (2003). Statistical mapping analysis of lesion location and neurological disability in multiple sclerosis: application to 452 patient data sets. Neuroimage, 19(3), 532-44.

    This is an interesting large-scale application of (essentially) VLSM.

  • Brett M, Johnsrude IS, Owen AM. (2002). The problem of functional localization in the human brain. Nat Rev Neurosci. 2002 Mar;3(3):243-9.

    Even though it's mostly about fMRI, this article on localization lays out issues of importance in using image data to localize function.