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Areas of Expertise

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Use of TMS as both a diagnostic tool and a treatment intervention is under study at the NCRRN (Coslett).

Kobayashi M, Pascual-Leone A. Transcranial magnetic stimulation in neurology. Lancet Neurol 2: 1-18, 2004.
A recent, review of TMS applications in a variety of neurologic conditions. (HBC)
Pascual-Leone A, Walsh V, Rothwell J. Transcranial magnetic stimulation in cognitive neuroscience – virtual lesion, chronometry and functional connectivity. Curr Opin Neurobiol 10: 232-237, 2000.
An up-to-date review of the applications of TMS in cognitive neuroscience by leaders of the field. (HBC)

Gough PM, Nobre AC, Devlin JT. Dissociating Linguistic Processes in the Left Interior Frontal Cortex with Transcranial Magnetic Stimulation. J Neurosci 25: 8010-8016, 2005.
An illustration of the spatial specificity afforded by TMS and its application to language. The authors demonstrated that TMS to the anterior LIFG interfered with judgments about meaning whereas TMS to the posterior LIFG interfered with judgments about phonology. (HBC)
Coslett HB, Monsul N. Reading with the right hemisphere: Evidence from Transcranial Magnetic Stimulation. Brain and Language 46: 198-211, 1994.
The first use of TMS to systematically explore the anatomic basis of written language. The study demonstrates the right hemisphere may mediate reading in subjects recovering from brain lesions. (HBC)

Cattaneo L, Voss M, Brochier T, Prabhu G, Wolpert DM, Lemon RN. A cortico-cortical mechanism mediating object-driven grasp in humans. PNAS 102: 898-903, 2005.
A double-pulse TMS study in normal subjects demonstrating that 600 ms. before object-driven action there is an increase in excitability in the primary motor cortex corresponding to the pattern of muscles used in the grasp. An excellent illustration of the manner in which TMS can be used to address fundamental issues of motor function. (HBC)
Glover S, Miall RC, Rushworth MFS. Parietal rTMS disrupts the initiation but not the execution of On-line adjustments to a perturbation of object size. J Cog Neurosci 17: 124-136, 2005.
An excellent illustration of the use of “on-line” TMS to delve into the issue of timing and on-line control of action. (HBC)