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Dr. Detre is the Principal Investigator of the University of Pennsylvania component of the NCRRN and Director of the Center for Functional Neuroimaging at Penn. He is Associate Professor of Neurology and Radiology and has longstanding experience in the development and validation of functional magnetic resonance imaging (fMRI) and other neuroimaging methods for basic and clinical neuroscience research.

Areas of Expertise

• Quantification of cerebral blood flow (CBF) using magnetic resonance imaging
• Physiology of functional activation
• Clinical applications of fMRI, including stroke, epilepsy, recovery of function
• Research career development

Programs of Research

• Perfusion MRI in cerebrovascular disease
• Perfusion MRI in cognitive neuroscience
• fMRI memory lateralization
• Neuroimaging in cognitive neurorehabilitation

Publications

• Detre, J.A. and T.F. Floyd (2000) Functional MRI and its applications to the clinical neurosciences. Neuroscientist, 7: 64-79. PMID 11486346
• Detre, J.A. and J. Wang (2002) Technical aspects and utility of fMRI using BOLD and ASL. Clin. Neurophysiol., 113: 621-634. PMID 11976042
• Aguirre, G.K., J.A. Detre and D.C. Alsop (2002) Experimental design and the relative sensitivity of BOLD and perfusion fMRI. Neuroimage, 15: 488-500. PMID 11848692
• Rabin, M.L., A.E. Salvucci, K. Tang, D.A. Mintzer, D.J. Casasanto, G. Glosser, J.A. French, M.R. Sperling, D.Y. Kimberg and J.A. Detre (2002) MRI predicts post-surgical memory outcome in temporal lobe epilepsy patients. Epilepsia, 43 Suppl. 7:90: 1.246. PMID 15329352
• Floyd, T.F., M.L. McGarvey, E.A. Ochroch, A.T. Cheung, J.A. Augoustides, J.E. Bavaria, M.A. Acker, A. Pochettino and J.A. Detre (2003) Perioperative changes in cerebral blood flow after cardiac surgery: Influence of anemia and aging. Ann. Thorac. Surg., 76: 2037-42. PMID 14667637
• Floyd, T.F., S.J. Ratcliffe, J.J. Wang, B. Resch and J.A. Detre (2003) Precision of the CASL-perfusion MRI technique: Global and regional cerebral blood flow within vascular territories at one hour and one week. J. Magn. Reson. Imaging, 18: 649-55. PMID 14635149
• Wang, J., G.K. Aguirre, D.Y. Kimberg, A.C. Roc, L. Li and J.A. Detre (2003) Arterial spin labeling perfusion fMRI with very low task frequency. Magn Reson Med, 49: 796-802. PMID 12704760
• Licht, D.J., J. Wang, D.W. Silvestre, S.C. Nicolson, L.M. Montenegro, G. Wernovsky, S. Tabbutt, S.M. Durning, D.M. Shera, J.W. Gaynor, T.L. Spray, R.R. Clancy, R.A. Zimmerman and J.A. Detre (2004) Preoperative cerebral blood flow is diminished in neonates with severe congenital heart defects. J Thorac Cardiovasc Surg, 128: 841-9. PMID 15573068
• Aguirre, G.K., J.A. Detre and J. Wang (2005) Perfusion fMRI for functional neuroimaging. Int Rev Neurobiol, 66: 213-36. PMID 16387205
• Fernandez-Seara, M.A., Z. Wang, J. Wang, H.Y. Rao, M. Guenther, D.A. Feinberg and J.A. Detre (2005) Continuous arterial spin labeling perfusion measurements using single shot 3D GRASE at 3 T. Magn Reson Med, 54: 1241-7. PMID 16193469
• Newberg, A.B., J. Wang, H. Rao, R.L. Swanson, J.S. Karp, A. Alavi, J.H. Greenberg and J.A. Detre (2005) Concurrent CBF and CMRGlc changes during human brain activation by combined fMRI-PET scanning. Neuroimage, 28: 500-6. PMID 16084114
• Wang, Z., J. Wang, T.J. Connick, G.S. Wetmore and J.A. Detre (2005) Continuous ASL perfusion MRI with an array coil and parallel imaging at 3T. Magn Reson Med, 54: 732-7. PMID 16086314
• Wang, J., H. Rao, G.S. Wetmore, P.M. Furlan, M. Korczykowski, D.F. Dinges and J.A. Detre (2005) Perfusion functional MRI reveals cerebral blood flow pattern under psychological stress. Proc Natl Acad Sci U S A, 102: 17804-9. PMID 16306271
• Roc, A.C., J. Wang, B.M. Ances, D.S. Liebeskind, S.E. Kasner and J.A. Detre (2006) Altered hemodynamics and regional cerebral blood flow in patients with hemodynamically significant stenoses. Stroke, 37: 382-7. PMID 16373653
• Kim, J., J. Whyte, J. Wang, H. Rao, K.Z. Tang and J.A. Detre (2006) Continuous ASL perfusion fMRI investigation of higher cognition: Quantification of tonic CBF changes during sustained attention and working memory tasks. Neuroimage. PMID 16427324
• Olson, I.R., H. Rao, K.S. Moore, J. Wang, J.A. Detre and G.K. Aguirre (2006) Using perfusion fMRI to measure continuous changes in neural activity with learning. Brain Cogn. PMID 16423439
• Jefferson, A.L., G. Glosser, J.A. Detre, G. Sinson and D.S. Liebeskind (2006) Neuropsychological and perfusion MR imaging correlates of revascularization in a case of moyamoya syndrome. AJNR Am J Neuroradiol, 27: 98-100. PMID 16418365
• Roc, A.C., J. Wang, B.M. Ances, D.S. Liebeskind, S.E. Kasner and J.A. Detre (2006) Altered hemodynamics and regional cerebral blood flow in patients with hemodynamically significant stenoses. Stroke, 37: 382-7. PMID 16373653
• Kim, J., B. Avants, S. Patel, J. Whyte, B.H. Coslett, J. Pluta, J.A. Detre and J.C. Gee (2007) Structural consequences of diffuse traumatic brain injury: A large deformation tensor-based morphometry study. Neuroimage. PMID 17999940
• Rao, H., S.J. Gillihan, J. Wang, M. Korczykowski, G.M. Sankoorikal, K.A. Kaercher, E.S. Brodkin, J.A. Detre and M.J. Farah (2007) Genetic variation in serotonin transporter alters resting brain function in healthy individuals. Biol Psychiatry, 62: 600-6. PMID 17481593
• Rao, H., J. Wang, K. Tang, W. Pan and J.A. Detre (2007) Imaging brain activity during natural vision using CASL perfusion fMRI. Hum Brain Mapp, 28: 593-601. PMID 17034034
• Wang, Z., G.K. Aguirre, H. Rao, J. Wang, M.A. Fernandez-Seara, A.R. Childress and J.A. Detre (2007) Empirical optimization of ASL data analysis using an ASL data processing toolbox: ASLtbx. Magn Reson Imaging. PMID 17826940
• Wang, Z., A.R. Childress, J. Wang and J.A. Detre (2007) Support vector machine learning-based fMRI data group analysis. Neuroimage, 36: 1139-51. PMID 17524674